The mechanisms that order cellular packing geometry are critical for the functioning of many
tissues, but they are poorly understood. Here, we investigate this problem in the developing …

Heterochromatin is important for gene regulation and chromosome structure, but the genes
that are occupied by heterochromatin proteins in the mammalian genome are largely …

Although cellular tumor-suppression mechanisms are widely studied, little is known about
mechanisms that act at the level of tissues to suppress the occurrence of aberrant cells in …

A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identity
by repressing differentiation genes, and abundant evidence points to an oncogenic role for …

While calcium signaling in excitable cells, such as muscle or neurons, is extensively
characterized, calcium signaling in epithelial tissues is little understood. Specifically, the range of …

Tissue homeostasis relies on the ability of tissues to respond to stress. Tissue regeneration
and tumour models in Drosophila have shown that c-Jun amino-terminal kinase (JNK) acts …

Epithelial repair relies on the activation of stress signaling pathways to coordinate tissue
repair. Their deregulation is implicated in chronic wound and cancer pathologies. Using TNF-α/…

10.7554/eLife.41036.001 The restoration of homeostasis after tissue damage relies on proper
spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In …

Tissue-intrinsic defense mechanisms eliminate aberrant cells from epithelia and thereby
maintain the health of developing tissues or adult organisms.‘Interface surveillance’comprises …

Drosophila pupal (P) wing development entails a series of dynamic developmental events,
such as epithelial and glial morphogenesis, that are of outstanding interest to cell biologists. …