The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To
this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of pro-…

Epidemiological studies established an association between chronic inflammation and higher
risk of cancer. Inhibition of proteolytic enzymes represents a potential treatment strategy …

10.7554/eLife.45571.001 Lung cancer and chronic lung diseases impose major disease
burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The …

… Author links open overlay panel Carla Guarino a 1 , Yveline Hamon a f 1 , Cécile Croix b
1 , Anne-Sophie Lamort a f , Sandrine Dallet-Choisy a , Sylvain Marchand-Adam a , Adam …

Background Survival after curative resection of early-stage lung adenocarcinoma (LUAD)
varies and prognostic biomarkers are urgently needed. Methods Large-format tissue samples …

Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural
cavity of asbestos‐exposed individuals and rapidly leads to death. MPM harbors loss‐of‐function …

… Chiara Colarusso, 1 Michela Terlizzi, 1 Anne-Sophie Lamort, 2 Ida Cerqua, 4 Fiorentina
Roviezzo, 4 Georgios Stathopoulos, 2, 3 Aldo Pinto, 1 and Rosalinda Sorrentino 1 …

Simple Summary Kirsten rat sarcoma virus (KRAS)-mutant cancers are frequent, metastatic,
lethal, and largely undruggable. The aim of this study was to investigate the pathways …

Cysteine cathepsin C (CatC) is a ubiquitously expressed, lysosomal aminopeptidase
involved in the activation of zymogens of immune-cell-associated serine proteinases (elastase, …