Although the neurogenesis-enhancing effects of exercise have been extensively studied,
the molecular mechanisms underlying this response remain unclear. Here, we propose that …

In vitro assays are valuable tools to study the characteristics of adult neural precursor cells
under controlled conditions with a defined set of parameters. We here present a detailed …

Background The trajectory of corticospinal tract (CST) axons from cortex to spinal cord involves
a succession of choice points, each of which is controlled by multiple guidance molecules…

Cellular redox states regulate the balance between stem cell maintenance and activation.
Increased levels of intracellular reactive oxygen species (ROS) are linked to proliferation and …

The establishment of connectivity between specific thalamic nuclei and cortical areas involves
a dynamic interplay between the guidance of thalamocortical axons and the elaboration of …

Psychiatric disorders such as schizophrenia and autism are characterised by cellular
disorganisation and dysconnectivity across the brain and can be caused by mutations in genes that …

L-lactate has energetic and signaling properties, and its availability is modulated by activity-dependent
stimuli, which also regulate adult hippocampal neurogenesis. Studying the …

Plexin-domain containing 2 (Plxdc2) is a relatively uncharacterised transmembrane protein
with an area of nidogen homology and a plexin repeat (PSI domain) in its extracellular region…

Mutations in the gene of the peripheral myelin protein zero (P0) give rise to the peripheral
neuropathies Charcot-Marie-Tooth type 1B disease (CMT1B), Déjérine-Sottas syndrome, and …

The neural cell adhesion molecule L1, a member of the immunoglobulin superfamily,
performs important functions in the developing and adult nervous system and is implicated in …