The neurotrophin (NT) brain-derived neurotrophic factor (BDNF) plays an essential role in
the formation of long-term potentiation (LTP). Here, we address whether this modulation by …

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic …

Deficiencies in fragile X mental retardation protein (FMRP) are the most common cause of
inherited intellectual disability, fragile X syndrome (FXS), with symptoms manifesting during …

Neurotrophins have been shown to play a critical role in activity-dependent synaptic
plasticity such as long-term potentiation (LTP) in the hippocampus. Although the role of brain-…

In previous experiments the activity-dependent secretion of nerve growth factor (NGF) from
native hippocampal slices and from NGF-cDNA transfected hippocampal neurons showed …

The precise polarization and orientation of developing neurons is essential for the correct
wiring of the brain. In pyramidal excitatory neurons, polarization begins with the sprouting of …

The establishment of neuronal connectivity depends on the correct initial polarization of the
young neurons. In vivo, developing neurons sense a multitude of inputs and a great number …

An essential step during the development of hippocampal neurons is the polarised outgrowth
of a single axon. Recently, it has been suggested that inhibition of glycogen synthase …

It is not clear to what extent restricted cell migration contributes to patterning of the developing
telencephalon, since both restricted and widespread cell migration have been observed. …

Neurotrophins (NTs) play an essential role in modulating activity‐dependent neuronal
plasticity. In this context, the site and extent of NT secretion are of crucial importance. Here, we …