Macrophages are innate immune cells that adopt diverse activation states in response to
their microenvironment. Editing macrophage activation to dampen inflammatory diseases by …

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

Aims Migration of monocytes into the arterial wall contributes to arterial inflammation and
atherosclerosis progression. Since elevated low-density lipoprotein cholesterol (LDL-C) levels …

Macrophages are key immune cells found in atherosclerotic plaques and critically shape
atherosclerotic disease development. Targeting the functional repertoire of macrophages may …

Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but
how systemic metabolism influences immune cell metabolism and function remains to be …

Macrophages represent a major immune cell population in atherosclerotic plaques and play
central role in the progression of this lipid-driven chronic inflammatory disease. Targeting …

We recap epigenetic features of distinct enhancers and describe the role of Jumonji domain-containing
protein 3 (Jmjd3) and Hdac3 as crucial mediators of macrophage differentiation, …

Atherosclerosis is associated with a compromised endothelial barrier, facilitating the
accumulation of immune cells and macromolecules in atherosclerotic lesions. In this study, we …

Macrophages form a heterogeneous population of immune cells, which is critical for both the
initiation and resolution of inflammation. They can be skewed to a proinflammatory subtype …

For yet unknown reasons, severely ill COVID-19 patients often become critically ill around
the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of …