[HTML][HTML] SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis

N Sima, A Dujeancourt-Henry, BL Perlaza… - …, 2022 - thelancet.com
Background To achieve elimination of Human African Trypanosomiasis (HAT) caused by
Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is …

[HTML][HTML] DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice

…, E Tihon, E McLaughlin, A Dujeancourt-Henry… - PLoS …, 2021 - journals.plos.org
Antigenic variation is an immune evasion strategy used by Trypanosoma brucei that results
in the periodic exchange of the surface protein coat. This process is facilitated by the …

The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

…, M Prorocic, A Dujeancourt-Henry… - Nucleic acids …, 2021 - academic.oup.com
Homologous recombination dominates as the major form of DNA repair in Trypanosoma
brucei, and is especially important for recombination of the subtelomeric variant surface …

Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

EJ McLaughlin, K Rubio-Pena, A Dujeancourt-Henry… - Mbio, 2022 - Am Soc Microbiol
In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein
(VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape …

Note: Phylogenetic position of rare human mycoplasmas. Mycoplasma faucium, M. buccale, M. primatum and M. spermatophilum, based on 16S rRNA gene …

G Rawadi, A Dujeancourt-Henry… - … of Systematic and …, 1998 - microbiologyresearch.org
The nucleotide sequence of the 16S rRNA genes of four rare human mycoplasma species.
Mycoplasma faucium, M. buccale, M. primatum and M. spermatophilum, were partially …

[HTML][HTML] VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei

…, K Rubio-Peña, A Dujeancourt-Henry… - Frontiers in Cell and …, 2022 - frontiersin.org
The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the
mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches …

Single locus phosphoproteomics reveals phosphorylation of RPA-1 is required for generation of single-strand DNA following a break at a subtelomeric locus

E McLaughlin, A Dujeancourt-Henry, T Chaze… - bioRxiv, 2022 - biorxiv.org
Damage to the genetic material of the cell poses a universal threat to all forms of life. Central
to the DNA damage response (DDR) is a phosphorylation signalling cascade that leads to …

RAD50 promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

AK Mehnert, M Prorocic, A Dujeancourt-Henry… - bioRxiv, 2020 - biorxiv.org
Homologous recombination dominates as the major form of DNA repair in Trypanosoma
brucei, and is especially important for recombination of the subtelomeric variant surface …

Characteristics associated with olfactory and taste disorders in COVID-19

S Galmiche, T Bruel, Y Madec, L Tondeur… - …, 2021 - karger.com
Introduction: Olfactory and taste disorders (OTDs) have been reported in COVID-19 caused
by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the mechanisms of …

[HTML][HTML] SARS-CoV-2 infection in schools in a northern French city: a retrospective serological cohort study in an area of high transmission, France, January to April …

A Fontanet, L Tondeur, R Grant, S Temmam… - …, 2021 - eurosurveillance.org
Background Children’s role in SARS-CoV-2 epidemiology remains unclear. We investigated
an initially unnoticed SARS-CoV-2 outbreak linked to schools in northern France, beginning …