The mouse ortholog of human FACE-1, Zmpste24, is a multispanning membrane protein
widely distributed in mammalian tissues 1, 2 and structurally related to Afc1p/ste24p, a yeast …

Klotho was discovered as an antiaging gene, and α-Klotho (Klotho) is expressed in multiple
tissues with a broad set of biologic functions. Membrane-bound Klotho binds fibroblast …

This study aims to provide a greater insight into how formative assessments are experienced
and understood by students. Two different formative assessment methods, an individual, …

Background An endemic of chronic kidney disease (CKD) of unknown cause among rural
inhabitants in Central America has been identified. Young and otherwise healthy men working …

Background In vivo models of uremia are important tools to study numerous aspects of
acute and chronic kidney disease. Mouse models are pivotal because most genetically …

The use of immunoisolation devices may allow transplantation without need for immunosuppression
and could widen the indications for cell transplantation. In this study, we evaluated …

Clinically, many candidates for islet transplantation are already immunized, which increases
their risk of graft rejection. Encapsulation of pancreatic islets using the TheraCyte™ device …

Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of
phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D–…

Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone
disorder. In order to validate its potential as a predictor of vascular calcification, we explored …

We analyzed the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) over
the past 2 decades. Between 1992 and 2009, 953 patients were treated with HSCT, mainly …