Brain tumors are among the most lethal and devastating cancers. Their study is limited by
genetic heterogeneity and the incompleteness of available laboratory models. Three-…

“Humanized” mouse models created by engraftment of immunodeficient mice with human
hematolymphoid cells or tissues are an emerging technology with broad appeal across …

Breast cancer is the most common female cancer, affecting approximately one in eight women
during their life-time. Besides environmental triggers and hormones, inherited mutations …

Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti‐angiogenic
treatment has limited efficacy due to therapy‐induced blood vessel alterations, often followed …

Fungal infections claim an estimated 1.5 million lives each year. Mechanisms that protect
from fungal infections are still elusive. Recognition of fungal pathogens relies on C-type lectin …

Muscle degeneration is the most prevalent cause for frailty and dependency in inherited
diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective …

Breast cancer is the most common nonskin cancer and is the second leading cause of
cancer-related deaths in women. Most methods of intervention involve combinations of surgery, …

Klebsiella pneumoniae is a significant cause of nosocomial pneumonia and an alarming
pathogen owing to the recent isolation of multidrug resistant strains. Understanding of immune …

Over 80% of patients with myeloproliferative neoplasms (MPNs) harbor the acquired
somatic JAK2 V617F mutation. JAK inhibition is not curative and fails to induce a persistent …

The HOIP ubiquitin E3 ligase generates linear ubiquitin chains by forming a complex with
HOIL ‐1L and SHARPIN in mammals. Here, we provide the first evidence of linear …