Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

Background Mutations in minor spliceosome components such as U12 snRNA (cerebellar
ataxia) and U4atac snRNA (microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1…

Mutation in minor spliceosome components is linked to the developmental disorder microcephalic
osteodysplastic primordial dwarfism type 1 (MOPD1). Here, we inactivated the minor …

Vertebrate genomes contain major (>99.5%) and minor (<0.5%) introns that are spliced by
the major and minor spliceosomes, respectively. Major intron splicing follows the exon-…

The emergence of introns was a significant evolutionary leap that is a major distinguishing
feature between prokaryotic and eukaryotic genomes. While historically introns were …

Splicing is a crucial regulatory node of gene expression that has been leveraged to expand
the proteome from a limited number of genes. Indeed, the vast increase in intron number that …

Background Splicing is crucial for proper gene expression, and is predominately executed
by the major spliceosome. Conversely, 722 introns in 699 human minor intron‐containing …

Minor intron–containing genes (MIGs) account for <2% of all human protein–coding genes
and are uniquely dependent on the minor spliceosome for proper excision. Despite their low …

Despite the high conservation of minor introns across eukaryotic supergroups, specific
lineages have completely lost minor intron splicing, which has raised questions about their …

When exposed to low temperature, homeothermic vertebrates maintain internal body
temperature by activating thermogenesis and by altered metabolism, synchronized by …