User profiles for Anqi Ma
 | Anqi MaBristol Myers Squibb Verified email at bms.com Cited by 2429 |
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis
Canonically, EZH2 serves as the catalytic subunit of PRC2, which mediates H3K27me3
deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 has …
deposition and transcriptional repression. Here, we report that in acute leukaemias, EZH2 has …
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote
tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases …
tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases …
Discovery of a first-in-class EZH2 selective degrader
The enhancer of zeste homolog 2 (EZH2) is the main enzymatic subunit of the PRC2
complex, which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to promote …
complex, which catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to promote …
Multiobjective optimization of a double-side linear Vernier PM motor using response surface method and differential evolution
This paper designs a double-side linear vernier permanent-magnet motor, which incorporates
the merits of high thrust force capability, high power factor, and high efficiency. Since the …
the merits of high thrust force capability, high power factor, and high efficiency. Since the …
Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8
The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes
monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been …
monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been …
[PDF][PDF] Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk neuroblastoma
Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook
chromatin-focused small interfering RNA and chemical screens to uncover epigenetic …
chromatin-focused small interfering RNA and chemical screens to uncover epigenetic …
Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2
Enhancer of zeste homolog 2 (EZH2), a catalytic subunit of polycomb repressive complex 2 (PRC2),
is overexpressed in triple-negative breast cancer (TNBC), correlating with poor …
is overexpressed in triple-negative breast cancer (TNBC), correlating with poor …
PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
Dysregulation of polycomb repressive complex 2 (PRC2) promotes oncogenesis partly
through its enzymatic function for inducing trimethylation of histone H3 lysine 27 (H3K27me3). …
through its enzymatic function for inducing trimethylation of histone H3 lysine 27 (H3K27me3). …
A deep-learning based citation count prediction model with paper metadata semantic features
A Ma, Y Liu, X Xu, T Dong - Scientometrics, 2021 - Springer
Predicting the impact of academic papers can help scholars quickly identify the high-quality
papers in the field. How to develop efficient predictive model for evaluating potential papers …
papers in the field. How to develop efficient predictive model for evaluating potential papers …