Mapping the spatial distribution and molecular identity of constituent cells is essential for
understanding tissue dynamics in health and disease. We lack a comprehensive map of human …

Using scRNA-seq and microscopy, we describe a cell that is enriched in the lower airways
of the developing human lung and identified by the unique coexpression of SCGB3A2/SFTPB/…

Bud tip progenitors (BTPs) in the developing lung give rise to all epithelial cell types found in
the airways and alveoli. This work aimed to develop an iPSC organoid model enriched with …

The human respiratory epithelium is derived from a progenitor cell in the distal buds of the
developing lung. These "bud tip progenitors" are regulated by reciprocal signaling with …

An abundance of information about lung development in animal models exists; however,
comparatively little is known about lung development in humans. Recent advances using …

Alveolar type 2 (AT2) cells function as stem cells in the adult lung and aid in repair after injury.
The current study aimed to understand the signaling events that control differentiation of …

Human intestinal organoids (HIOs) derived from human pluripotent stem cells co-differentiate
both epithelial and mesenchymal lineages in vitro but lack important cell types such as …

Recent advances using single cell genomic approaches have identified new epithelial cell
types and uncovered cellular heterogeneity in the murine and human lung ( 1 ). Here, using …

Fibroblast growth factors (FGFs) 9 and 10 are essential during the pseudoglandular stage of
lung development. Mesothelium-produced FGF9 is principally responsible for mesenchymal …

… Moreover, in supervised training the network can overfit on the instrument(s) used in acquiring
the … p r e c i s i o n = t r u e p o s . a l l … F 1 - S c o r e = 2 p r e c i s i o n - 1 + r e c a l l - 1 . …