BMP/SMAD signaling is a crucial regulator of intestinal differentiation 1 , 2 , 3 – 4 . However,
the molecular underpinnings of the BMP pathway in this context are unknown. Here, we …

The cell of origin of colon cancer is typically thought to be the resident somatic stem cells,
which are immortal and escape the continual cellular turnover characteristic of the intestinal …

The gut epithelium has a remarkable ability to recover from damage. We employed a combination
of high-throughput sequencing approaches, mouse genetics, and murine and human …

Oncogenic mutations in BRAF are believed to initiate serrated colorectal cancers; however,
the mechanisms of BRAF-driven colon cancer are unclear. We find that oncogenic BRAF …

The intestinal stem cell fuels the highest rate of tissue turnover in the body and has been
implicated in intestinal disease and cancer; understanding the regulatory mechanisms …

Transcriptional regulatory mechanisms likely contribute to the etiology of inflammatory bowel
disease (IBD), as genetic variants associated with the disease are disproportionately found …

BACKGROUND & AIMS: Protein tyrosine kinase 6 (PTK6) is expressed in epithelial linings
of the gastrointestinal tract. PTK6 sensitizes the nontransformed Rat1a fibroblast cell line to …

During late gestation, villi extend into the intestinal lumen to dramatically increase the
surface area of the intestinal epithelium, preparing the gut for the neonatal diet. Incomplete …

Disruption of the gene encoding Protein Tyrosine Kinase 6 (Ptk6) delayed differentiation
and increased growth in the mouse intestine. However, Ptk6-null mice were also resistant to …

Hypoxia-inducible factor 2α (HIF2α) directly regulates a battery of genes essential for
intestinal iron absorption. Interestingly, iron deficiency and overload disorders do not result in …