The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of
discontinuous cisternae. Glycosylation enzymes are usually concentrated in one or two specific …

Glycosyltransferases are a large family of enzymes responsible for covalently linking sugar
monosaccharides to a variety of organic substrates. These enzymes drive the synthesis of …

A significant lacuna in academic and scientific studies of consciousness is a description of
how it actually feels to be here. The study of consciousness has proved to be extremely …

Thymidylate kinase (TMK) is a key enzyme that plays an important role in DNA synthesis.
Therefore, it serves as an attractive therapeutic target for the development of antibacterial, …

Severe sepsis or septic shock is one of the rising causes for mortality worldwide representing
nearly 10% of intensive care unit admissions. Susceptibility to sepsis is identified to be …

Thymidylate kinase ( TMK ) is a key enzyme which plays an important role in DNA synthesis.
It belongs to the family of nucleoside monophosphate kinases, several of which undergo …

In the recent decades, essential steps of protein structure determination such as phasing by
multiple isomorphous replacement and multi wave length anomalous dispersion, molecular …

Glycans are important regulators of cell and organismal physiology. This requires that the
glycan biosynthesis be controlled to achieve specific cellular glycan profiles. Glycans are …

c-Jun N-terminal kinase (JNK), a member of the MAPK family, is associated with a variety of
diseases and immune responses. To dissect the mechanistic role of JNKs in such processes…

To obtain selective and potent opioid receptor ligands, we synthesized dehydro derivatives
of alvimopan and found compound (28f), a selective but modest affinity MOR antagonist …