The intestinal epithelium is a rapidly renewing cellular compartment. This constant regeneration
is a hallmark of intestinal homeostasis and requires a tightly regulated balance between …

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-dimensional
in vitro human distal lung culture systems would strongly facilitate the …

Cell stress and infection promote the formation of ubiquitinated aggregates in both non-immune
and immune cells. These structures are recognised by the autophagy receptor p62/…

Modulation of Wnt signaling has untapped potential in regenerative medicine due to its
essential functions in stem cell homeostasis. However, Wnt lipidation and Wnt-Frizzled (Fzd) …

Procollagens, pre-chylomicrons, and pre–very low-density lipoproteins (pre-VLDLs) are too
big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported …

Autoinducer‐2 (AI‐2) a signal produced by a range of phylogenetically distant microorganisms,
enables inter‐species cell–cell communication and regulates many bacterial phenotypes…

10.7554/eLife.02784.001 TANGO1 binds and exports Procollagen VII from the endoplasmic
reticulum (ER). In this study, we report a connection between the cytoplasmic domain of …

10.7554/eLife.32723.001 Collagen export from the endoplasmic reticulum (ER) requires
TANGO1, COPII coats, and retrograde fusion of ERGIC membranes. How do these components …

10.7554/eLife.10982.001 Previously we showed that membrane fusion is required for
TANGO1-dependent export of procollagen VII from the endoplasmic reticulum (ER) ( Nogueira, et …

Tissue-resident immunity underlies essential host defenses against pathogens, but analysis
in humans has lacked in vitro model systems where epithelial infection and accompanying …