Common activation mechanism of class A GPCRs
…, D Yang, M Wu, Y Guo, W Guo, L Zhong, X Cai, A Dai… - Elife, 2019 - elifesciences.org
Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …
physiology. Understanding receptor activation mechanism is critical for discovering novel …
Targeted dual-contrast T1-and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide …
Abstract Development of a multifunctional nanoparticle (NP) system allowing for dual-contrast
T 1 - and T 2 -weighted targeted magnetic resonance (MR) imaging of tumors could …
T 1 - and T 2 -weighted targeted magnetic resonance (MR) imaging of tumors could …
[HTML][HTML] Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
…, K Hang, X Zou, C Zhang, Y Chen, A Dai… - Nature …, 2022 - nature.com
Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP),
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several multi-…
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several multi-…
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
…, C De Graaf, Q Zhou, S Jiang, K Liu, X Cai, A Dai… - Nature, 2017 - nature.com
The glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are
members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and have …
members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and have …
Structure of the full-length glucagon class B G-protein-coupled receptor
H Zhang, A Qiao, D Yang, L Yang, A Dai, C De Graaf… - Nature, 2017 - nature.com
The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor
family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes…
family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes…
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
…, K Zhou, D Wang, X Wang, J Du, C Yi, X Chu, A Dai… - Nature, 2021 - nature.com
The metabotropic glutamate receptors (mGlus) have key roles in modulating cell excitability
and synaptic transmission in response to glutamate (the main excitatory neurotransmitter in …
and synaptic transmission in response to glutamate (the main excitatory neurotransmitter in …
Structure and dynamics of the active human parathyroid hormone receptor-1
…, LJ Clark, FG Jean-Alphonse, AD White, D Yang, A Dai… - Science, 2019 - science.org
The parathyroid hormone receptor-1 (PTH1R) is a class BG protein–coupled receptor central
to calcium homeostasis and a therapeutic target for osteoporosis and hypoparathyroidism. …
to calcium homeostasis and a therapeutic target for osteoporosis and hypoparathyroidism. …
Structural basis of Gs and Gi recognition by the human glucagon receptor
A Qiao, S Han, X Li, Z Li, P Zhao, A Dai, R Chang, L Tai… - Science, 2020 - science.org
Class BG protein–coupled receptors, an important class of therapeutic targets, signal mainly
through the G s class of heterotrimeric G proteins, although they do display some …
through the G s class of heterotrimeric G proteins, although they do display some …
[HTML][HTML] Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Cholecystokinin A receptor (CCK A R) belongs to family A G-protein-coupled receptors and
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
Structure of the glucagon receptor in complex with a glucagon analogue
…, L Yang, N Van Eps, KS Frederiksen, D Yang, A Dai… - Nature, 2018 - nature.com
Class B G-protein-coupled receptors (GPCRs), which consist of an extracellular domain (ECD)
and a transmembrane domain (TMD), respond to secretin peptides to play a key part in …
and a transmembrane domain (TMD), respond to secretin peptides to play a key part in …