A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several
of which are known to control gene expression. The repertoire and regulation of lncRNAs …

Genetic studies promise to provide insight into the molecular mechanisms underlying type 2
diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer …

Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human
pancreatic β cells. β cell lncRNAs are often cell type specific and exhibit dynamic regulation …

The transcription factor neurogenin 3 (Neurog3 or Ngn3) controls islet cell fate specification
in multipotent pancreatic progenitor cells in the mouse embryo. However, our knowledge of …

Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the
cellular and molecular processes that generate them are poorly understood. Here, we perform a …

The transcriptional programs of differentiated cells are tightly regulated by interactions
between cell type-specific transcription factors and cis-regulatory elements. Long non-coding …

At least 10 enteroendocrine cell types have been identified, and the peptide hormones they
secrete have diverse functions that include regulation of glucose homeostasis, food intake, …

Intestinal hormones are key regulators of digestion and energy homeostasis secreted by
rare enteroendocrine cells. These cells produce over ten different hormones including GLP-1 …

Ulcerative colitis (UC), Crohn’s disease (CD), and celiac disease are prevalent intestinal
inflammatory disorders with nonsatisfactory therapeutic interventions. Analyzing patient data-…

Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated
in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The …