Water is the solvent used by nature for biological chemistry. Considering the enormous
variety of biological organic synthetic pathways and the complicated molecular structures and …

Fragment-based approaches to finding novel small molecules that bind to proteins are now
firmly established in drug discovery and chemical biology. Initially developed primarily in a …

Organic reactions that occur at the water interface for water-insoluble compounds, and
reactions in water solution for water soluble compounds, has added a powerful dimension to …

Fragment-based approaches have now become firmly established in the drug discovery
armoury. After notable early successes against protein kinases, the versatility and power of …

The nature of the rate enhancements caused by gradually increasing the mole fraction of
water in the solvent (from 0 to 1) for the cycloaddition reactions of pyridazinium-…

Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments
are needed to combat emergence of drug resistance. Inosine 5′-monophosphate …

… Anthony G. Coyne Anthony Coyne received his BSc (1998) and PhD (2002) from the
National University of Ireland, Galway, working with Richard Butler. He accepted an …

Given the frequent use of DMSO in biochemical and biophysical assays, it is desirable to
understand the influence of DMSO concentration on the dissociation or unfolding behavior of …

The essential enzyme CYP121 is a target for drug development against antibiotic resistant
strains of Mycobacterium tuberculosis. A triazol-1-yl phenol fragment 1 was identified to bind …

Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous
mycobacteria that has emerged as a growing threat to individuals with cystic fibrosis …