The AcrAB–TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis

AM Buckley, MA Webber, S Cooles… - Cellular …, 2006 - Wiley Online Library
The ability of an isogenic set of mutants of Salmonella enterica serovar Typhimurium L354 (SL1344)
with defined deletions in genes encoding components of tripartite efflux pumps, …

[HTML][HTML] Comprehensive Assignment of Roles for Salmonella Typhimurium Genes in Intestinal Colonization of Food-Producing Animals

…, J Wang, PM van Diemen, AM Buckley… - PLoS …, 2013 - journals.plos.org
Chickens, pigs, and cattle are key reservoirs of Salmonella enterica, a foodborne pathogen
of worldwide importance. Though a decade has elapsed since publication of the first …

Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo

…, J Spencer, KR Hargreaves, AM Buckley… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The microbiome dysbiosis caused by antibiotic treatment has been associated with both
susceptibility to and relapse of Clostridium difficile infection (CDI). Bacteriophage (phage) …

[HTML][HTML] The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile

…, KE Mackin, J Spencer, AM Buckley… - PLoS …, 2011 - journals.plos.org
Nosocomial infections are increasingly being recognised as a major patient safety issue. The
modern hospital environment and associated health care practices have provided a niche …

Evaluation of live-attenuated Salmonella vaccines expressing Campylobacter antigens for control of C. jejuni in poultry

AM Buckley, J Wang, DL Hudson, AJ Grant, MA Jones… - Vaccine, 2010 - Elsevier
Campylobacter jejuni is a zoonotic bacterial pathogen of worldwide importance. It is estimated
that 460,000 human infections occur in the United Kingdom per annum and these involve …

[HTML][HTML] LOV-based reporters for fluorescence imaging

AM Buckley, J Petersen, AJ Roe, GR Douce… - Current opinion in …, 2015 - Elsevier
… panel Anthony M Buckley 1 , Jan Petersen 2 , Andrew J Roe 1 , Gillian R Douce 1 , John M
… Adapted from Buckley et al. [58]. (c) Tobacco mosaic virus (TMV)-based expression of iLOV …

[HTML][HTML] Biofilms harbour Clostridioides difficile, serving as a reservoir for recurrent infection

…, MR Henn, CB Ford, MH Wilcox, AM Buckley - NPJ biofilms and …, 2021 - nature.com
C. difficile infection (CDI) is a worldwide healthcare problem with ~30% of cases failing
primary therapy, placing a burden on healthcare systems and increasing patient morbidity. We …

Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291

AM Buckley, J Spencer, D Candlish… - Journal of medical …, 2011 - microbiologyresearch.org
Clostridium difficile is the main cause of antibiotic-associated disease, a disease of high
socio-economical importance that has recently been compounded by the global spread of the …

New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability

JA Kirk, D Gebhart, AM Buckley, S Lok… - Science translational …, 2017 - science.org
There is a medical need for antibacterial agents that do not damage the resident gut
microbiota or promote the spread of antibiotic resistance. We recently described a prototypic …

[HTML][HTML] Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains

AM Buckley, C Jukes, D Candlish, JJ Irvine… - Scientific reports, 2016 - nature.com
The uses of fluorescent reporters derived from green fluorescent protein have proved invaluable
for the visualisation of biological processes in bacteria grown under aerobic conditions. …