Compelling evidence shows that brown and beige adipose tissue are protective against
metabolic diseases 1 , 2 . PR domain-containing 16 (PRDM16) is a dominant activator of the …

Exercise capacity is a strong predictor of all-cause mortality. Skeletal muscle mitochondrial
respiratory capacity, its biggest contributor, adapts robustly to changes in energy demands …

Aberrant lipid metabolism promotes the development of skeletal muscle insulin resistance,
but the exact identity of lipid-mediated mechanisms relevant to human obesity remains …

Barth Syndrome (BTHS) is an X-linked recessive disorder characterized by cardiomyopathy
and muscle weakness. The underlying cause of BTHS is a mutation in the tafazzin (TAZ) …

De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white
adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report …

Objective Sarcolipin (SLN) regulates muscle energy expenditure through its action on sarco/endoplasmic
reticulum Ca 2+ ‐ATPase (SERCA) pump. It is unknown whether SLN‐…

The biophysical environment of membrane phospholipids affects the structure, function, and
stability of membrane-bound proteins 1 , 2 . Obesity can disrupt membrane lipids, and, in …

Obesity alters skeletal muscle lipidome and promotes myopathy, but it is unknown whether
aberrant muscle lipidome contributes to the reduction in skeletal muscle contractile force-…

Excess reactive oxygen species (ROS) induced by physical inactivity is associated with
muscle atrophy and muscle weakness. However, the role of mitochondrial ROS on disuse-…

Reactive oxygen species (ROS) accumulation is a cardinal feature of skeletal muscle atrophy.
ROS refers to a collection of radical molecules whose cellular signals are vast, and it is …