Regulation of integrin affinity (activation) is essential for metazoan development and for
many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to …

Previous experiments on the cystic fibrosis transmembrane conductance regulator suggested
that non‐native polar residues within membrane domains can compromise protein …

Regulated changes in the affinity of integrin adhesion receptors ("activation") play an important
role in numerous biological functions including hemostasis, the immune response, and …

Integrin adhesion receptors transduce bidirectional signals across the plasma membrane,
with the integrin transmembrane domains acting as conduits in this process. Here, we report …

In vitro studies indicate that binding of talin to the β 3 integrin cytoplasmic domain (tail) results
in integrin α IIb β 3 (GPIIb–IIIa) activation. Here we tested the importance of talin binding …

Targeted degradation approaches such as proteolysis targeting chimeras (PROTACs) offer
new ways to address disease through tackling challenging targets and with greater potency, …

Mutations to RAS proteins (H-, N-, and K-RAS) are among the most common oncogenic
drivers, and tumors harboring these lesions are some of the most difficult to treat. Although …

Studies that focus on packing interactions between transmembrane (TM) helices in membrane
proteins would greatly benefit from the ability to investigate their association and packing …

Macrocyclic α-helical peptides have emerged as a compelling new therapeutic modality to
tackle targets confined to the intracellular compartment. Within the scope of hydrocarbon-…

Macrocyclic peptides open new opportunities to target intracellular protein–protein interactions
(PPIs) that are often considered nondruggable by traditional small molecules. However, …