[HTML][HTML] Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate
proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain …
proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain …
[HTML][HTML] The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection
…, D Jiménez-Fernández, K Leandro, A Beling… - Nature …, 2019 - nature.com
ISG15 is an interferon-stimulated, ubiquitin-like protein, with anti-viral and anti-bacterial
activity. Here, we map the endogenous in vivo ISGylome in the liver following Listeria …
activity. Here, we map the endogenous in vivo ISGylome in the liver following Listeria …
Heart-specific immune responses in an animal model of autoimmune-related myocarditis mitigated by an immunoproteasome inhibitor and genetic ablation
…, A Kratzer, K Klingel, HA Katus, Z Kaya, A Beling - Circulation, 2020 - Am Heart Assoc
Background: Immune checkpoint inhibitor (ICI) therapy is often accompanied by immune-related
pathology, with an increasing occurrence of high-risk ICI-related myocarditis. …
pathology, with an increasing occurrence of high-risk ICI-related myocarditis. …
Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming
Protein modification with ISG15 (ISGylation) represents a major type I IFN–induced antimicrobial
system. Common mechanisms of action and species-specific aspects of ISGylation, …
system. Common mechanisms of action and species-specific aspects of ISGylation, …
Development of a new mouse model for coxsackievirus-induced myocarditis by attenuating coxsackievirus B3 virulence in the pancreas
…, Z Kaya, M El-Shafeey, A Beling… - Cardiovascular …, 2020 - academic.oup.com
Aims The coxsackievirus B3 (CVB3) mouse myocarditis model is the standard model for
investigation of virus-induced myocarditis but the pancreas, rather than the heart, is the most …
investigation of virus-induced myocarditis but the pancreas, rather than the heart, is the most …
[HTML][HTML] Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
…, J Ho, SW van Leur, WWS Ng, LYL Siu, A Beling… - Nature …, 2021 - nature.com
Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) (ISG15) is a ubiquitin-like modifier
induced during infections and involved in host defense mechanisms. Not surprisingly, …
induced during infections and involved in host defense mechanisms. Not surprisingly, …
The immunoproteasome‐specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis
…, S Pinkert, Z Kaya, K Klingel, A Beling - EMBO molecular …, 2018 - embopress.org
Severe heart pathology upon virus infection is closely associated with the immunological
equipment of the host. Since there is no specific treatment available, current research focuses …
equipment of the host. Since there is no specific treatment available, current research focuses …
[HTML][HTML] Cysteine-reactive free ISG15 generates IL-1β–producing CD8α+ dendritic cells at the site of infection
…, A Borg, D Frith, S Howell, S Kjaer, A Beling… - The Journal of …, 2018 - journals.aai.org
IFN-stimulated gene (ISG) 15 is a ubiquitin-like protein induced after type I IFN stimulation.
There is a dearth of in vivo models to study free unconjugated ISG15 function. We found that …
There is a dearth of in vivo models to study free unconjugated ISG15 function. We found that …
[HTML][HTML] Silencing the CSF-1 axis using nanoparticle encapsulated siRNA mitigates viral and autoimmune myocarditis
…, B Meder, HA Katus, K Klingel, A Beling… - Frontiers in …, 2018 - frontiersin.org
Myocarditis is an inflammatory disease of the heart muscle most commonly caused by viral
infection and often maintained by autoimmunity. Virus-induced tissue damage triggers …
infection and often maintained by autoimmunity. Virus-induced tissue damage triggers …
Early Treatment of Coxsackievirus B3–Infected Animals With Soluble Coxsackievirus-Adenovirus Receptor Inhibits Development of Chronic Coxsackievirus B3 …
Background: Coxsackie-B-viruses (CVB) are frequent causes of acute myocarditis and dilated
cardiomyopathy, but an effective antiviral therapy is still not available. Previously, we and …
cardiomyopathy, but an effective antiviral therapy is still not available. Previously, we and …