Neutrophils perform critical functions in the innate response to infection, including through
the production of neutrophil extracellular traps (NETs) - web-like DNA structures which are …

Microarray - assisted gene - expression screens of human macrophages revealed WNT5A, a
homolog of Wingless, a key regulator of Drosophila melanogaster embryonic segmentation …

In the FANTOM5 project, transcription initiation events across the human and mouse genomes
were mapped at a single base-pair resolution and their frequencies were monitored by …

Mycobacterium tuberculosis employs various virulence strategies to subvert host immune
responses in order to persist and cause disease. Interaction of M. tuberculosis with mannose …

Mitochondria have a multitude of functions, including energy generation and cell signaling.
Recent evidence suggests that mitochondrial dynamics (ie the balance between …

In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium
tuberculosis (Mtb) and constructed an Mtb mutant lacking the biotin biosynthetic enzyme …

Naturally occurring regulatory T (Treg) cells, which specifically express the transcription
factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-…

The secreted hexameric form of the dengue virus (DENV) non‐structural protein 1 (NS1)
has recently been shown to elicit inflammatory cytokine release and disrupt endothelial cell …

Background The endoplasmic reticulum (ER) stress pathway known as the Unfolded Protein
Response (UPR) is an adaptive survival pathway that protects cells from the buildup of …

Tuberculosis (TB) remains a major global health threat. Urgent needs in the fight against TB
include improved and innovative treatment options for drug-sensitive and -resistant TB as …