Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis

…, I Levy, G Li, VA Magnotta, A Manthey… - Molecular …, 2021 - nature.com
Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple
regions of the cerebral cortex. However, findings for many regions, particularly regions outside …

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

…, LAM Lebois, G Li, VA Magnotta, A Manthey… - Molecular …, 2021 - nature.com
A growing number of studies have examined alterations in white matter organization in people
with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have …

Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups

…, A Maron‐Katz, A Sierk, A Manthey… - Brain and …, 2022 - Wiley Online Library
Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated
aging. Estimates of brain age, compared to chronological age, may clarify the effects of …

[HTML][HTML] A comparison of methods to harmonize cortical thickness measurements across scanners and sites

…, B Suarez-Jimenez, A Sierk, H Walter, A Manthey… - Neuroimage, 2022 - Elsevier
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific
profiles in participants’ demographic and clinical characteristics, as well as MRI …

Does trauma-focused psychotherapy change the brain? A systematic review of neural correlates of therapeutic gains in PTSD

A Manthey, A Sierk, EL Brakemeier… - European Journal of …, 2021 - Taylor & Francis
Background: Meta-analytic results indicate that posttraumatic stress disorder (PTSD) is
associated with hypoactivation of the medial prefrontal cortex (mPFC), hyperactivation of the …

Neural correlates of acute post-traumatic dissociation: a functional neuroimaging script-driven imagery study

YL Mertens, A Manthey, A Sierk, H Walter… - BJPsych Open, 2022 - cambridge.org
Background Current neurobiological models of post-traumatic stress disorder (PTSD) assume
excessive medial frontal activation and hypoactivation of cortico-limbic regions as neural …

White matter network alterations in patients with depersonalization/derealization disorder

A Sierk, JK Daniels, A Manthey, JG Kok… - Journal of Psychiatry and …, 2018 - jpn.ca
Background: Depersonalization/derealization disorder (DPD) is a chronic and distressing
condition characterized by detachment from oneself and/or the external world. Neuroimaging …

[HTML][HTML] The dissociative subtype of posttraumatic stress disorder is associated with subcortical white matter network alterations

A Sierk, A Manthey, EL Brakemeier, H Walter… - Brain imaging and …, 2021 - Springer
Posttraumatic stress disorder (PTSD) is characterized by intrusions, avoidance, and hyperarousal
while patients of the dissociative subtype (PTSD-D) experience additional dissociative …

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

…, L Wang, Y Zhu, G Li, A Sierk, A Manthey… - …, 2024 - nature.com
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in
prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some …

[HTML][HTML] Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

…, AR Hudson, SC Mueller, A Sierk, A Manthey… - Molecular …, 2024 - nature.com
Although the cerebellum contributes to higher-order cognitive and emotional functions relevant
to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is …