Prior to clinical development, a comprehensive pharmacokinetic characterization of a novel
drug is required to understand its exposure at the site of action and elimination. Accordingly, …

PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin–proteasome system to
degrade a protein of interest for therapeutic benefit. Advances made in targeted protein …

Animal pharmacokinetic (PK) data as well as human and animal in vitro systems are utilized
in drug discovery to define the rate and route of drug elimination. Accurate prediction and …

Tetracyclines are broad-spectrum antibiotics used to prevent or treat a variety of bacterial
infections. Resistance is often mediated through mobile resistance genes, which encode one …

This paper presents a parameter-free perfectly matched layer (PML) method for the finite-element-based
solution of the Helmholtz equation. We employ one of Bermúdez et al.'s …

The gold‐standard approach for modeling pharmacokinetic mediated drug–drug
interactions is the use of physiologically‐based pharmacokinetic modeling and population …

Combination therapy or concomitant drug administration can be associated with pharmacokinetic
drug–drug interactions, increasing the risk of adverse drug events and reduced drug …

We investigate the theoretical foundations of the simulated tempering (ST) method and use
our findings to design an efficient accelerated sampling algorithm. Employing a large …

In this thesis we discuss accelerated sampling schemes for high dimensional systems, for
example molecular dynamics (MD). The development of these methods is fundamental to the …

A detailed understanding of wind turbine performance status classification can improve
operations and maintenance in the wind energy industry. Due to different engineering properties …