User profiles for Anton Wellstein
 | Anton WellsteinGeorgetown University Verified email at georgetown.edu Cited by 15848 |
Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development
A Aigner, PE Ray, F Czubayko, A Wellstein - Histochemistry and cell …, 2002 - Springer
Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development.
FGF-2 (basic FGF, bFGF) is widely expressed in the embryo and has been linked to tissue …
FGF-2 (basic FGF, bFGF) is widely expressed in the embryo and has been linked to tissue …
[HTML][HTML] Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
…, D Wen, A Karavanov, AT Riegel, A Wellstein - Journal of Biological …, 2001 - ASBMB
Pleiotrophin (PTN) is a secreted growth factor that induces neurite outgrowth and is mitogenic
for fibroblasts, epithelial, and endothelial cells. During tumor growth PTN can serve as an …
for fibroblasts, epithelial, and endothelial cells. During tumor growth PTN can serve as an …
[HTML][HTML] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
…, ET Bowden, EB Sale, AT Riegel, A Wellstein - Journal of Biological …, 2002 - ASBMB
Midkine (MK) is a developmentally regulated, secreted growth factor homologous to
pleiotrophin (PTN). To investigate the potential role of MK in tumor growth, we expressed MK in …
pleiotrophin (PTN). To investigate the potential role of MK in tumor growth, we expressed MK in …
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma
…, F Wang, B Kallakury, J Toretsky, A Wellstein… - Science …, 2014 - science.org
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
A secreted FGF-binding protein can serve as the angiogenic switch in human cancer
The growth and metastatic spread of cancer is directly related to tumor angiogenesis 1 , and
the driving factors need to be understood to exploit this process therapeutically 2,3 . …
the driving factors need to be understood to exploit this process therapeutically 2,3 . …
[HTML][HTML] Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth
…, A Aigner, GE Stoica, K McDonnell, A Wellstein - Journal of Biological …, 2002 - ASBMB
Glioblastoma multiforme is the most common highly aggressive human brain cancer, and
receptor tyrosine kinases have been implicated in the progression of this malignancy. We have …
receptor tyrosine kinases have been implicated in the progression of this malignancy. We have …
Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus
…, F Czubayko, AT Riegel, A Wellstein - Proceedings of the …, 1996 - National Acad Sciences
Retroviral elements are found in abundance throughout the human genome but only rarely
have alterations of endogenous genes by retroviral insertions been described. Herein we …
have alterations of endogenous genes by retroviral insertions been described. Herein we …
[HTML][HTML] The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis
…, Y Tomita, A Preet, F Palmieri, A Wellstein… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Dysregulation of the pathways that preserve mitochondrial integrity hallmarks many human
diseases including diabetes, neurodegeration, aging and cancer. The mitochondrial citrate …
diseases including diabetes, neurodegeration, aging and cancer. The mitochondrial citrate …
[HTML][HTML] Effect of estradiol on estrogen receptor-α gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway
…, E Morgan, MC Iann, AD Winder, R Reiter, A Wellstein… - Oncogene, 2003 - nature.com
Epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and heregulin-β1 (HRG-β1),
can modulate the expression and activity of the estrogen receptor-α (ER-α) via the …
can modulate the expression and activity of the estrogen receptor-α (ER-α) via the …
[HTML][HTML] Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein
…, K McDonnell, A Karavanov, A Wellstein - Journal of Biological …, 2001 - ASBMB
Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind
fibroblast growth factors (FGFs) 1 and 2. These FGFs are typically stored on heparan sulfate …
fibroblast growth factors (FGFs) 1 and 2. These FGFs are typically stored on heparan sulfate …