[PDF][PDF] Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets
…, DYH Soong, T Cotechini, P Anur, EY Lin, A Fidanza… - Cancer cell, 2019 - cell.com
The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and …
cancer are poorly understood. Here, we show that monocyte subpopulation distribution and …
Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs
A Fidanza, PS Stumpf, P Ramachandran… - Blood, The Journal …, 2020 - ashpublications.org
Hematopoietic stem and progenitor cells (HSPCs) develop in distinct waves at various
anatomical sites during embryonic development. The in vitro differentiation of human pluripotent …
anatomical sites during embryonic development. The in vitro differentiation of human pluripotent …
Activation of KLF1 enhances the differentiation and maturation of red blood cells from human pluripotent stem cells
…, R Ma, RA Axton, M Jackson, AH Taylor, A Fidanza… - Stem Cells, 2017 - academic.oup.com
Blood transfusion is widely used in the clinic but the source of red blood cells (RBCs) is
dependent on donors, procedures are susceptible to transfusion-transmitted infections and …
dependent on donors, procedures are susceptible to transfusion-transmitted infections and …
[HTML][HTML] Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
M Lopez-Yrigoyen, CT Yang, A Fidanza… - Nature …, 2019 - nature.com
Red blood cells mature within the erythroblastic island (EI) niche that consists of specialized
macrophages surrounded by differentiating erythroblasts. Here we establish an in vitro …
macrophages surrounded by differentiating erythroblasts. Here we establish an in vitro …
[PDF][PDF] Exogenous expression of human protamine 1 (hPrm1) remodels fibroblast nuclei into spermatid-like structures
D Iuso, M Czernik, P Toschi, A Fidanza, F Zacchini… - Cell reports, 2015 - cell.com
Protamines confer a compact structure to the genome of male gametes. Here, we find that
somatic cells can be remodeled by transient expression of protamine 1 (Prm1). Ectopically …
somatic cells can be remodeled by transient expression of protamine 1 (Prm1). Ectopically …
A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and in vivo tracking of therapeutic cells
M Lopez-Yrigoyen, A Fidanza… - … of the Royal …, 2018 - royalsocietypublishing.org
We describe the production of a human induced pluripotent stem cell (iPSC) line, SFCi55-ZsGr,
that has been engineered to express the fluorescent reporter gene, ZsGreen, in a …
that has been engineered to express the fluorescent reporter gene, ZsGreen, in a …
Post-implantation mortality of in vitro produced embryos is associated with DNA methyltransferase 1 dysfunction in sheep placenta
GE Ptak, A D'Agostino, P Toschi, A Fidanza… - Human …, 2013 - academic.oup.com
STUDY QUESTION Is DNA methyltransferase 1 (DNMT1) dysfunction involved in epigenetic
deregulation of placentae from embryos obtained by assisted reproduction technologies (…
deregulation of placentae from embryos obtained by assisted reproduction technologies (…
[HTML][HTML] Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases
Uncovering the mechanisms regulating hematopoietic specification not only would overcome
current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation…
current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation…
Impaired placental vasculogenesis compromises the growth of sheep embryos developed in vitro
A Fidanza, P Toschi, F Zacchini, M Czernik… - Biology of …, 2014 - academic.oup.com
To evaluate how assisted reproductive technologies (ART) affect vasculogenesis of the
developing conceptus, we analyzed placental and fetal development of in vitro-produced (IVP) …
developing conceptus, we analyzed placental and fetal development of in vitro-produced (IVP) …
A short exposure to polychlorinated biphenyls deregulates cellular autophagy in mammalian blastocyst in vitro
BACKGROUND Polychlorinated biphenyls (PCBs) are common environmental contaminants
that represent an important risk factor of reproductive disorders in chronically exposed …
that represent an important risk factor of reproductive disorders in chronically exposed …