Senescence is a cellular stress response that results in the stable arrest of old, damaged or
pre-neoplastic cells. Oncogene-induced senescence is tumour suppressive but can also …

Macrophages undergo profound metabolic reprogramming upon sensing infectious and
sterile stimuli. This metabolic shift supports and regulates essential innate immune functions, …

Iron is an essential metal that fine-tunes the innate immune response by regulating
macrophage function, but an integrative view of transcriptional and metabolic responses to iron …

Macrophage activation in response to stimulation of Toll‐like receptor 4 (TLR4) provides a
paradigm for investigating energy metabolism that regulates the inflammatory response. TLR4…

In response to environmental stimuli, macrophages change their nutrient consumption and
undergo an early metabolic adaptation that progressively shapes their polarization state. …

Cell membrane fusion and multinucleation in macrophages are associated with physiologic
homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb …

Toll-like receptor 4 (TLR4)-mediated changes in macrophages reshape intracellular lipid
pools to coordinate an effective innate immune response. Although this has been previously …

Background and Purpose Cardiac glycosides inhibit Na + /K + ‐ATPase and are used to treat
heart failure and arrhythmias. They can induce inflammasome activation and pyroptosis in …

Objective When molecular drivers of healthy adipogenesis are perturbed, this can cause
hepatic steatosis. The role of arachidonic acid (AA) and its downstream enzymatic cascades, …

Colorectal and prostate cancers are major causes of cancer-related death, with early detection
key to increased survival. However, as symptoms occur during advanced stages and …