Vα24-invariant natural killer T cells (NKTs) have anti-tumor properties that can be enhanced
by chimeric antigen receptors (CARs). Here we report updated interim results from the first-in…

Multimodal single-cell assays provide high-resolution snapshots of complex cell populations,
but are mostly limited to transcriptome plus an additional modality. Here, we describe …

Vα24-invariant natural killer T (NKT) cells have shown potent anti-tumor properties in murine
tumor models and have been linked to favorable outcomes in patients with cancer. However…

CRISPR screens have been used to connect genetic perturbations with changes in gene
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …

The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas nuclease
system is a powerful tool for genome editing, and its simple programmability has enabled high-…

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component.
Molecular pathways involving the homeodomain transcription factor Shox2 control the …

T cells engineered with CD28-based CARs possess robust effector function and antigen
sensitivity but are hampered by limited persistence, which may result in tumor relapse. We …

Mutations in the homeobox gene SHOX cause SHOX deficiency, a condition with clinical
manifestations ranging from short stature without dysmorphic signs to severe mesomelic …

Height is a complex quantitative trait with a high heritability. Short stature is diagnosed when
height is significantly below the average of the general population for that person’s age and …

Pooled CRISPR screens have been used to identify genes responsible for specific
phenotypes and diseases, and, more recently, to connect genetic perturbations with multi-…