Background Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the
treatment of arterial hypertension and cardiovascular diseases. Our objective was to study …

For general spin systems, we prove that a contractive coupling for an arbitrary local Markov
chain implies optimal bounds on the mixing time and the modified log-Sobolev constant for a …

Cardiac fibrosis is a pathogenic factor in a variety of cardiovascular diseases and is
characterized by an abnormal accumulation of extracellular matrix protein that leads to cardiac …

Purpose Arterial hypertension is associated with a high production of reactive oxygen
species and a decrease in the antioxidant defense systems. Based on the lack of toxicity of l-…

Leptin is a protein involved in the regulation of food intake and in the immune and
inflammatory responses, among other functions. Evidences demonstrate that obesity is directly …

BACKGROUND The development of renal fibrosis is a consequence of arterial hypertension.
L-carnitine plays an essential role in the β-oxidation of fatty acids, and we have previously …

k-mer-based methods are widely used in bioinformatics, but there are many gaps in our
understanding of their statistical properties. Here, we consider the simple model where a …

Sunitinib (Su) is currently approved for treatment of several malignances. However, along
with the benefits of disease stabilization, cardiovascular toxicities have also been increasingly …

Motivation Sketching is now widely used in bioinformatics to reduce data size and increase
data processing speed. Sketching approaches entice with improved scalability but also carry …

The random-cluster model is a unifying framework for studying random graphs, spin systems
in physics and random spanning trees. The model is closely related to, though much more …