User profiles for Antonio C Ruzzini

Antonio Ruzzini

Assistant Professor, University of Saskatchewan
Verified email at mail.usask.ca
Cited by 762

Selvamicin, an atypical antifungal polyene from two alternative genomic contexts

EB Van Arnam, AC Ruzzini, CS Sit… - Proceedings of the …, 2016 - National Acad Sciences
The bacteria harbored by fungus-growing ants produce a variety of small molecules that help
maintain a complex multilateral symbiosis. In a survey of antifungal compounds from these …

Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants

CS Sit, AC Ruzzini, EB Van Arnam… - Proceedings of the …, 2015 - National Acad Sciences
Small molecules produced by Actinobacteria have played a prominent role in both drug
discovery and organic chemistry. As part of a larger study of the actinobacterial symbionts of …

[HTML][HTML] Pyrazines from bacteria and ants: convergent chemistry within an ecological niche

EA Silva-Junior, AC Ruzzini, CR Paludo… - Scientific reports, 2018 - nature.com
Ants use pheromones to coordinate their communal activity. Volatile pyrazines, for instance,
mediate food resource gathering and alarm behaviors in different ant species. Here we …

A rebeccamycin analog provides plasmid-encoded niche defense

EB Van Arnam, AC Ruzzini, CS Sit… - Journal of the …, 2015 - ACS Publications
Bacterial symbionts of fungus-growing ants occupy a highly specialized ecological niche
and face the constant existential threat of displacement by another strain of ant-adapted …

Tryptorubin A: A polycyclic peptide from a fungus-derived streptomycete

TP Wyche, AC Ruzzini, L Schwab… - Journal of the …, 2017 - ACS Publications
Fungus-growing ants engage in complex symbiotic relationships with their fungal crop,
specialized fungal pathogens, and bacteria that provide chemical defenses. In an effort to …

Linear peptides are the major products of a biosynthetic pathway that encodes for cyclic depsipeptides

TP Wyche, AC Ruzzini, C Beemelmanns, KH Kim… - Organic …, 2017 - ACS Publications
Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium
isolated from a South African termite, Macrotermes natalensis. The structures of the complex …

[HTML][HTML] Investigation of Macrolide Resistance Genotypes in Mycoplasma bovis Isolates from Canadian Feedlot Cattle

…, TA McAllister, R Zaheer, M Waldner, AC Ruzzini… - Pathogens, 2020 - mdpi.com
Mycoplasma bovis is associated with bovine respiratory disease (BRD) and chronic pneumonia
and polyarthritis syndrome (CPPS) in feedlot cattle. No efficacious vaccines for M. bovis …

[PDF][PDF] Gene flow and molecular innovation in bacteria

AC Ruzzini, J Clardy - Current Biology, 2016 - cell.com
The small molecules produced by environmental bacteria have been mainstays of both
chemical and biological research for decades, and some have led to important therapeutic …

Identification of an Acyl-Enzyme Intermediate in a meta-Cleavage Product Hydrolase Reveals the Versatility of the Catalytic Triad

AC Ruzzini, S Ghosh, GP Horsman… - Journal of the …, 2012 - ACS Publications
Meta-cleavage product (MCP) hydrolases are members of the α/β-hydrolase superfamily
that utilize a Ser-His-Asp triad to catalyze the hydrolysis of a CC bond. BphD, the MCP …

Metabolites Involved in Immune Evasion by Batrachochytrium dendrobatidis Include the Polyamine Spermidine

LA Rollins-Smith, AC Ruzzini, JS Fites… - Infection and …, 2019 - Am Soc Microbiol
Amphibians have been declining around the world for more than four decades. One recognized
driver of these declines is the chytrid fungus Batrachochytrium dendrobatidis , which …