Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing …

Germline mutations in CYBB, the human gene encoding the gp91 phox subunit of the phagocyte
NADPH oxidase, impair the respiratory burst of all types of phagocytes and result in X-…

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent
infection to lethal disease. The role of human genetics in determining clinical response to …

Chronic granulomatous disease (CGD) is an immunodeficiency disorder affecting about 1 in
250,000 individuals. The disease is caused by a lack of superoxide production by the …

This is the second report on the continuing efforts of LAGID to increase the recognition and
registration of patients with primary immunodeficiency diseases in 12 Latin American …

Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12– and IL-23–dependent IFN-γ
immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 …

Patients with mutations of the recombination-activating genes (RAG) present with diverse
clinical phenotypes, including severe combined immune deficiency (SCID), autoimmunity, and …

Introduction During the last 4 decades, registration of patients with primary immunodeficiencies
(PID) has played an essential role in different aspects of these diseases worldwide …

Background We previously reported that impaired type I IFN activity, due to inborn errors of
TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type …