Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β
plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to …

Background MSA is a fatal neurodegenerative disease characterized by autonomic failure
and severe motor impairment. Its main pathological hallmark is the accumulation of α‐…

In the past few years, an increasing amount of studies primarily based on experimental
models have investigated the existence of distinct α-synuclein strains and their different …

Multiple system atrophy (MSA) is a fatal, adult-onset neurodegenerative disorder that has
no cure and very limited treatment options. MSA is characterized by deposition of fibrillar α-…

Objective Cognitive impairment in multiple system atrophy (MSA) is common, but remain
poorly characterized. We evaluated cognitive and behavioral features in MSA patients and …

Background Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of α-synucleinopathies
including Parkinson’s disease and multiple system atrophy, and its …

Since its discovery 30 years ago, α-synuclein (α-syn) has been one of the most studied proteins
in the field of neuroscience. Dozens of groups worldwide have tried to reveal not only its …

Background Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized
by intracellular accumulations of α‐synuclein and nerve cell loss in striatonigral and …

Background Multiple system atrophy (MSA) is a fatal neurodegenerative disorder
characterized by aggregated α‐synuclein (α‐syn) in oligodendrocytes and accompanied by …

Early adaptive responses to hypoxia are essential for cell survival, but their nature and
underlying mechanisms are poorly known. We have studied the post-transcriptional changes in …