Purpose This study aimed to assess the efficacy of the combination of nivolumab (nivo) plus
ipilimumab (ipi) as a first-line therapy with respect to the 12-month overall survival (OS) in …

Immune mechanisms have evolved to cope with local entry of microbes acting in a confined
fashion but eventually inducing systemic immune memory. Indeed, in situ delivery of a …

Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment
and have both tumor-promoting and tumor-suppressive functions. This SnapShot …

In Burkitt lymphoma/leukemia (BL), achievement of complete remission with first-line
chemotherapy remains a challenging issue, as most patients who respond remain disease-free, …

Cancer-associated fibroblasts (CAFs) perform diverse roles and can modulate therapy
responses 1 . The inflammatory environment within tumours also influences responses to many …

Uveal melanoma (UM) is a rare disease that can be deadly in spite of adequate local treatment.
Systemic therapy with chemotherapy is usually ineffective and new-targeted therapies …

Diverse extracellular matrix patterns are observed in both normal and pathological tissue.
However, most current tools for quantitative analysis focus on a single aspect of matrix …

Radiotherapy is one of the most effective and frequently used treatments for a wide range of
cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment …

Computational histology-based stromal phenotypes within the tumor microenvironment are
significantly associated with prognosis and immune exclusion in melanoma. …

The emergence of immunotherapy, in the form of immune checkpoint inhibitors, has irrevocably
altered the paradigm of cancer treatment over the past decade. Multiple characteristics of …