White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in
regulating energy homeostasis and insulin sensitivity. WAT is characterised by its capacity to …

Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk 1 , 2 . More than 60% of this effect is attributable to the …

β cells sense glucose through its metabolism and the resulting increase in ATP, which
subsequently stimulates insulin secretion. Uncoupling protein-2 (UCP2) mediates mitochondrial …

This review focuses on adipose tissue biology and introduces the concept of adipose tissue
plasticity and expandability as key determinants of obesity-associated metabolic …

While the link between obesity and type 2 diabetes is clear on an epidemiological level, the
underlying mechanism linking these two common disorders is not as clearly understood. …

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …

PPARγ is a member of the PPAR subfamily of nuclear receptors. In this work, the structure of
the human PPARγ cDNA and gene was determined, and its promoters and tissue-specific …

AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade
that acts as a gauge of cellular energy levels. Over the last few years, accumulating evidence …

Recent studies in murine models suggest that resistin (also called Fizz3 [ 1 ]), a novel
cysteine-rich protein secreted by adipocytes, may represent the long-sought link between obesity …

Uncoupling proteins (UCPs) are inner mitochondrial membrane transporters which dissipate
the proton gradient, releasing stored energy as heat. UCP1 is expressed exclusively in …