Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
SL Nutt, B Heavey, AG Rolink, M Busslinger - Nature, 1999 - nature.com
The Pax5 gene encoding the B-cell-specific activator protein (BSAP) is expressed within the
haematopoietic system exclusively in the B-lymphoid lineage, where it is required in vivo for …
haematopoietic system exclusively in the B-lymphoid lineage, where it is required in vivo for …
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
…, M Hinterberger, J Emmerich, LK Swee, A Rolink… - Nature …, 2007 - nature.com
The parameters specifying whether autoreactive CD4 + thymocytes are deleted (recessive
tolerance) or differentiate into regulatory T cells (dominant tolerance) remain unresolved. …
tolerance) or differentiate into regulatory T cells (dominant tolerance) remain unresolved. …
Cutting edge: human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
Leukocyte activation can be negatively regulated by inhibitory receptors specific for MHC
class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all …
class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all …
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement
…, TMJ Leu, DG Schatz, A Werner, AG Rolink… - Immunity, 1995 - cell.com
Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light
chain gene loci form functional immunoglobulin genes during B cell development. In mouse …
chain gene loci form functional immunoglobulin genes during B cell development. In mouse …
Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
AG Rolink, SL Nutt, F Melchers, M Busslinger - Nature, 1999 - nature.com
The mechanisms controlling the commitment of haematopoietic progenitors to the B-lymphoid
lineage are poorly understood. The observations that mice deficient in E2A 1 , 2 and EBF …
lineage are poorly understood. The observations that mice deficient in E2A 1 , 2 and EBF …
Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus …
SL Nutt, P Urbanek, A Rolink… - Genes & …, 1997 - genesdev.cshlp.org
The Pax5 gene coding for the transcription factor BSAP has an essential role in B
lymphopoiesis and midbrain development. Here we present a detailed analysis of the B-cell …
lymphopoiesis and midbrain development. Here we present a detailed analysis of the B-cell …
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion
…, H Nagaoka, M Jankovic, Z Misulovin, H Suh, A Rolink… - Nature, 1999 - nature.com
Abstract Models of B-cell development in the immune system suggest that only those
immature B cells in the bone marrow that undergo receptor editing express V (D)J -recombination-…
immature B cells in the bone marrow that undergo receptor editing express V (D)J -recombination-…
Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.
J Kirberg, A Baron, S Jakob, A Rolink… - The Journal of …, 1994 - rupress.org
We describe mice that express a transgenic T cell receptor alpha/beta (TCR-alpha/beta)
specific for peptide 111-119 from influenza hemagglutinin presented by I-Ed class II major …
specific for peptide 111-119 from influenza hemagglutinin presented by I-Ed class II major …
The chemokine SDF‐1, stromal cell‐derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4
M D'Apuzzo, A Rolink, M Loetscher… - European journal of …, 1997 - Wiley Online Library
In the bone marrow, progenitor (pro‐) and precursor (pre‐) B cells depend on close contact
with stromal cells for growth and maturation. Stromal cell‐derived factor 1 (SDF‐1), also …
with stromal cells for growth and maturation. Stromal cell‐derived factor 1 (SDF‐1), also …
[HTML][HTML] Identification of BSAP (Pax‐5) target genes in early B‐cell development by loss‐and gain‐of‐function experiments
SL Nutt, AM Morrison, P Dörfler, A Rolink… - The EMBO …, 1998 - embopress.org
The Pax‐5 gene codes for the transcription factor BSAP which is essential for the progression
of adult B lymphopoiesis beyond an early progenitor (pre‐BI) cell stage. Although several …
of adult B lymphopoiesis beyond an early progenitor (pre‐BI) cell stage. Although several …