Human lungs enable efficient gas exchange and form an interface with the environment, which
depends on mucosal immunity for protection against infectious agents. Tightly controlled …

Objective: Immunological mechanisms are involved in the pathophysiology of preeclampsia.
During pregnancy there is an increase in regulatory T (Treg) cells, which has an important …

Rationale: Asthma is a chronic inflammatory airway disease that affects more than 300
million individuals worldwide. Asthma is caused by interaction of genetic and environmental …

Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality.
Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of …

Background WNT signalling is activated during lung tissue damage and inflammation. We
investigated whether lung epithelial expression of WNT ligands, receptors (frizzled; FZD) or …

The molecular basis for airway epithelial fragility in asthma has remained unclear. We
investigated whether the loss of caveolin-1, the major component of caveolae and a known …

BACKGROUND: Regulatory T–cell dysfunction is associated with development of the complex
genetic conditions atopy and asthma. Therefore, we hypothesized that single nucleotide …

Background Changes in microRNA (miRNA) expression can contribute to the pathogenesis
of many diseases, including asthma. We aimed to identify miRNAs that are differentially …

Approximately 40% of asthmatics experience remission of asthma symptoms. A better
understanding of biological pathways leading to asthma remission may provide insight into new …

In chronic obstructive pulmonary disease (COPD), oxidative stress regulates the
inflammatory response of bronchial epithelium and monocytes/macrophages through kinase …