Key points Brief dopamine events are critical actors of reward‐mediated learning in the
striatum; the intracellular cAMP–protein kinase A (PKA) response of striatal medium spiny …

Transient changes in striatal dopamine (DA) concentration are considered to encode a reward
prediction error (RPE) in reinforcement learning tasks. Often, a phasic DA change occurs …

… Author links open overlay panel Anu G. Nair a b c 1 , Liliana RV Castro d e , Marianne El
Khoury e f , … M 1 is primarily coupled to G q/11 and stimulates the Protein Kinase C and inositol …

The basal ganglia are involved in the motivational and habitual control of motor and cognitive
behaviors. Striatum, the largest basal ganglia input stage, integrates cortical and thalamic …

Motivation Dynamical models describing intracellular phenomena are increasing in size and
complexity as more information is obtained from experiments. These models are often over-…

Presynaptic homeostatic plasticity (PHP) stabilizes synaptic transmission by counteracting
impaired neurotransmitter receptor function through neurotransmitter release potentiation. …

Long-term potentiation and depression of synaptic activity in response to stimuli is a key
factor in reinforcement learning. Strengthening of the corticostriatal synapses depends on the …

In reward learning, the integration of NMDA-dependent calcium and dopamine by striatal
projection neurons leads to potentiation of corticostriatal synapses through CaMKII/PP1 …

Although it is known that protein kinase A (PKA) in the nucleus regulates gene expression,
the specificities of nuclear PKA signaling remain poorly understood. Here, we combined …

Striatum, which is the input nucleus of the basal ganglia, integrates cortical and thalamic
glutamatergic inputs with dopaminergic afferents from the substantia nigra pars compacta. The …