User profiles for Anuja Sathe
Anuja SatheStanford University Verified email at stanford.edu Cited by 1381 |
[HTML][HTML] scPred: accurate supervised method for cell-type classification from single-cell RNA-seq data
Single-cell RNA sequencing has enabled the characterization of highly specific cell types in
many tissues, as well as both primary and stem cell-derived cell lines. An important facet of …
many tissues, as well as both primary and stem cell-derived cell lines. An important facet of …
Single-cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironment
Purpose: The tumor microenvironment (TME) consists of a heterogenous cellular milieu that
can influence cancer cell behavior. Its characteristics have an impact on treatments such as …
can influence cancer cell behavior. Its characteristics have an impact on treatments such as …
[PDF][PDF] An expanded universe of cancer targets
The characterization of cancer genomes has provided insight into somatically altered genes
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …
Targeting the PI3K/AKT/mTOR pathway in bladder cancer
A Sathe, R Nawroth - Urothelial carcinoma: Methods and protocols, 2018 - Springer
The PI3K/AKT/mTOR signaling pathway shows frequent molecular alterations alterations
and increased activity in cancer. Given its role in the regulation of cell growth, survival and …
and increased activity in cancer. Given its role in the regulation of cell growth, survival and …
Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution
Cancer cell lines are not homogeneous nor are they static in their genetic state and biological
properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to …
properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to …
Single-cell analysis can define distinct evolution of tumor sites in follicular lymphoma
Tumor heterogeneity complicates biomarker development and fosters drug resistance in
solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical …
solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical …
[HTML][HTML] Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells
Genome sequencing studies have identified numerous cancer mutations across a wide
spectrum of tumor types, but determining the phenotypic consequence of these mutations …
spectrum of tumor types, but determining the phenotypic consequence of these mutations …
Integrative single-cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer
Cancer progression is driven by both somatic copy number aberrations (CNAs) and chromatin
remodeling, yet little is known about the interplay between these two classes of events in …
remodeling, yet little is known about the interplay between these two classes of events in …
[HTML][HTML] Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy
A Sathe, G Chalaud, I Oppolzer, KY Wong… - PloS one, 2018 - journals.plos.org
Targeting the PI3K pathway has achieved limited success in cancer therapy. One reason for
the disappointing activity of drugs that interfere with molecules that are important player in …
the disappointing activity of drugs that interfere with molecules that are important player in …
Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated SPP1+ Macrophages and Fibroblasts
Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its microenvironment
is modified to provide a niche that is conducive for colorectal cancer cell growth. This …
is modified to provide a niche that is conducive for colorectal cancer cell growth. This …