User profiles for Anuja Sathe

Anuja Sathe

Stanford University
Verified email at stanford.edu
Cited by 1381

[HTML][HTML] scPred: accurate supervised method for cell-type classification from single-cell RNA-seq data

J Alquicira-Hernandez, A Sathe, HP Ji, Q Nguyen… - Genome biology, 2019 - Springer
Single-cell RNA sequencing has enabled the characterization of highly specific cell types in
many tissues, as well as both primary and stem cell-derived cell lines. An important facet of …

Single-cell genomic characterization reveals the cellular reprogramming of the gastric tumor microenvironment

A Sathe, SM Grimes, BT Lau, J Chen, C Suarez… - Clinical Cancer …, 2020 - AACR
Purpose: The tumor microenvironment (TME) consists of a heterogenous cellular milieu that
can influence cancer cell behavior. Its characteristics have an impact on treatments such as …

[PDF][PDF] An expanded universe of cancer targets

…, K Karagyozova, YH Lo, K Liu, M Nakano, A Sathe… - Cell, 2021 - cell.com
The characterization of cancer genomes has provided insight into somatically altered genes
across tumors, transformed our understanding of cancer biology, and enabled tailoring of …

Targeting the PI3K/AKT/mTOR pathway in bladder cancer

A Sathe, R Nawroth - Urothelial carcinoma: Methods and protocols, 2018 - Springer
The PI3K/AKT/mTOR signaling pathway shows frequent molecular alterations alterations
and increased activity in cancer. Given its role in the regulation of cell growth, survival and …

Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution

N Andor, BT Lau, C Catalanotti, A Sathe… - NAR Genomics and …, 2020 - academic.oup.com
Cancer cell lines are not homogeneous nor are they static in their genetic state and biological
properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to …

Single-cell analysis can define distinct evolution of tumor sites in follicular lymphoma

S Haebe, T Shree, A Sathe, G Day… - Blood, The Journal …, 2021 - ashpublications.org
Tumor heterogeneity complicates biomarker development and fosters drug resistance in
solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical …

[HTML][HTML] Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells

HS Kim, SM Grimes, T Chen, A Sathe, BT Lau… - Nature …, 2023 - nature.com
Genome sequencing studies have identified numerous cancer mutations across a wide
spectrum of tumor types, but determining the phenotypic consequence of these mutations …

Integrative single-cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer

CY Wu, BT Lau, HS Kim, A Sathe, SM Grimes… - Nature …, 2021 - nature.com
Cancer progression is driven by both somatic copy number aberrations (CNAs) and chromatin
remodeling, yet little is known about the interplay between these two classes of events in …

[HTML][HTML] Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy

A Sathe, G Chalaud, I Oppolzer, KY Wong… - PloS one, 2018 - journals.plos.org
Targeting the PI3K pathway has achieved limited success in cancer therapy. One reason for
the disappointing activity of drugs that interfere with molecules that are important player in …

Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated SPP1+ Macrophages and Fibroblasts

A Sathe, K Mason, SM Grimes, Z Zhou, BT Lau… - Clinical Cancer …, 2023 - AACR
Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its microenvironment
is modified to provide a niche that is conducive for colorectal cancer cell growth. This …