User profiles for Anwesha Nag
 | Anwesha NagDana Farber Cancer Institute Verified email at DFCI.harvard.edu Cited by 2693 |
Genetic and transcriptional evolution alters cancer cell line drug response
Human cancer cell lines are the workhorse of cancer research. Although cell lines are known
to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity …
to evolve in culture, the extent of the resultant genetic and transcriptional heterogeneity …
miR319a targeting of TCP4 is critical for petal growth and development in Arabidopsis
A Nag, S King, T Jack - Proceedings of the National …, 2009 - National Acad Sciences
In a genetic screen in a drnl-2 background, we isolated a loss-of-function allele in miR319a (miR319a
129 ). Previously, miR319a has been postulated to play a role in leaf development …
129 ). Previously, miR319a has been postulated to play a role in leaf development …
Cas9 activates the p53 pathway and selects for p53-inactivating mutations
Cas9 is commonly introduced into cell lines to enable CRISPR–Cas9-mediated genome
editing. Here, we studied the genetic and transcriptional consequences of Cas9 expression …
editing. Here, we studied the genetic and transcriptional consequences of Cas9 expression …
[HTML][HTML] Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel …
LE MacConaill, RT Burns, A Nag, HA Coleman… - BMC genomics, 2018 - Springer
Background Sample index cross-talk can result in false positive calls when massively parallel
sequencing (MPS) is used for sensitive applications such as low-frequency somatic variant …
sequencing (MPS) is used for sensitive applications such as low-frequency somatic variant …
Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations
…, G Soca-Chafre, N Patterson, AR Thorner, A Nag… - Cancer discovery, 2021 - AACR
The frequency of somatic EGFR and KRAS mutations in lung cancer varies by ethnicity, but
we do not understand why. Our study suggests that the variation in EGFR and KRAS …
we do not understand why. Our study suggests that the variation in EGFR and KRAS …
Detection of mutations in Barrett's esophagus before progression to high-grade dysplasia or adenocarcinoma
Background & Aims Barrett’s esophagus (BE) is the greatest risk factor for esophageal
adenocarcinoma (EAC), but only a small proportion of patients with BE develop cancer. …
adenocarcinoma (EAC), but only a small proportion of patients with BE develop cancer. …
Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion
Classical Hodgkin lymphoma (cHL) is composed of rare malignant Hodgkin Reed-Sternberg
(HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS …
(HRS) cells within an extensive, but ineffective, inflammatory/immune cell infiltrate. HRS …
Detection of somatic structural variants enables quantification and characterization of circulating tumor DNA in children with solid tumors
…, AN Clapp, S Meyer, A Ward, C Clinton, A Nag… - JCO precision …, 2018 - ascopubs.org
Objective Liquid biopsies are being rapidly used in adult cancers as new biomarkers of disease.
Circulating tumor DNA (ctDNA) levels have been reported to be proportional to disease …
Circulating tumor DNA (ctDNA) levels have been reported to be proportional to disease …
[HTML][HTML] Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group
…, K Klega, A Imamovic-Tuco, A Clapp, A Nag… - British journal of …, 2018 - nature.com
Background New prognostic markers are needed to identify patients with Ewing sarcoma (EWS)
and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence …
and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence …
Chromatin signature of widespread monoallelic expression
10.7554/eLife.01256.001 In mammals, numerous autosomal genes are subject to mitotically
stable monoallelic expression (MAE), including genes that play critical roles in a variety of …
stable monoallelic expression (MAE), including genes that play critical roles in a variety of …