Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells.
Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in …

Aims/hypothesis The G q -coupled 5-hydroxytryptamine 2B (5-HT 2B ) receptor is known to
regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin …

The sweet taste receptors present in the taste buds are heterodimers comprised of T1R2
and T1R3. This receptor is also expressed in pancreatic β-cells. When the expression of …

Objective Insulin release from pancreatic β-cells is controlled by plasma glucose levels via
mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on …

We reported recently that the taste type 1 receptor 3 (T1R3), a subunit of the sweet taste
receptor, functions as a cell-surface glucose-sensing receptor in pancreatic β-cells. In the …

Serotonin (5-HT) is a biogenic monoamine that functions both as a neurotransmitter and a
circulating hormone. Recently, the metabolic effects of 5-HT have gained interest and …

Aims/hypothesis Genetic studies show coupling of genes affecting beta cell function to type
1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis …

Institute for Molecular & Cellular Regulation, Gunma University, Maebashi 371-8512, Japan
abstract. The mechanism that initiates regeneration of pancreatic β-cells is not clear at …

In an earlier study, infection of human pancreatic islets with epidemic strains of echovirus (E4,
E16, E30), with proven but differently ability to induce islet autoimmunity, resulted either in …

Glycogen metabolism in β‐cells may affect downstream metabolic pathways controlling
insulin release. We examined glycogen metabolism in human islets and in the rodent‐derived …