Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D) 1 , 2 ; however, most of these loci have …

Despite widespread clinical genetic testing, many individuals with suspected genetic
conditions lack a precise diagnosis, limiting their opportunity to take advantage of state-of-the-art …

Background Transcranial alternating current stimulation (tACS) is a non-invasive brain
stimulation modality that may modulate cognition by enhancing endogenous neocortical …

Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, key tissues and …

Alternate splicing events can create isoforms that alter gene function, and genetic variants
associated with alternate gene isoforms may reveal molecular mechanisms of disease. We …

Loci identified in genome-wide association studies (GWAS) can include multiple distinct
association signals. We sought to identify the molecular basis of multiple association signals for …

Cortical oscillations modulate cellular excitability and facilitate neuronal communication and
information processing. Layer 5 pyramidal cells (L5 PYs) drive low-frequency oscillations (<…

Most signals detected by genome-wide association studies map to non-coding sequence and
their tissue-specific effects influence transcriptional regulation. However, many key tissues …

Whole-genome sequencing (WGS) can improve assessment of low-frequency and rare
variants, particularly in non-European populations that have been underrepresented in existing …

Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are heritable risk
factors for cardiovascular disease, yet the molecular mechanisms underlying the majority of …