[PDF][PDF] Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity
SJ Lee, AB Hwang, C Kenyon - Current Biology, 2010 - cell.com
A mild inhibition of mitochondrial respiration extends the life span of many organisms,
including yeast, worms, flies, and mice [1–10], but the underlying mechanism is unknown. One …
including yeast, worms, flies, and mice [1–10], but the underlying mechanism is unknown. One …
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
AB Hwang, EA Ryu, M Artan… - Proceedings of the …, 2014 - National Acad Sciences
Mild inhibition of mitochondrial respiration extends the lifespan of many species. In
Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-…
Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-…
[HTML][HTML] Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
AB Hwang, SJ Lee - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
A mild reduction in mitochondrial respiration extends the life span of many species, including
C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the …
C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the …
Mitochondria and organismal longevity
Mitochondria are essential for various biological processes including cellular energy production.
The oxidative stress theory of aging proposes that mitochondria play key roles in aging …
The oxidative stress theory of aging proposes that mitochondria play key roles in aging …
Aging induces aberrant state transition kinetics in murine muscle stem cells
JC Kimmel, AB Hwang, A Scaramozza… - …, 2020 - journals.biologists.com
Murine muscle stem cells (MuSCs) experience a transition from quiescence to activation
that is required for regeneration, but it remains unknown if the trajectory and dynamics of …
that is required for regeneration, but it remains unknown if the trajectory and dynamics of …
[HTML][HTML] Hearing loss prevalence and years lived with disability, 1990–2019: findings from the Global Burden of Disease Study 2019
Background Hearing loss affects access to spoken language, which can affect cognition and
development, and can negatively affect social wellbeing. We present updated estimates …
development, and can negatively affect social wellbeing. We present updated estimates …
Muscle stem cells and aging
AB Hwang, AS Brack - Current topics in developmental biology, 2018 - Elsevier
Satellite cells (SCs) are a population of muscle-resident stem cells that are essential for efficient
tissue repair. SCs reside in a relatively quiescent state during normal tissue turnover, but …
tissue repair. SCs reside in a relatively quiescent state during normal tissue turnover, but …
Mitochondrial chaperone HSP‐60 regulates anti‐bacterial immunity via p38 MAP kinase signaling
Mitochondria play key roles in cellular immunity. How mitochondria contribute to organismal
immunity remains poorly understood. Here, we show that HSP ‐60/ HSPD 1, a major …
immunity remains poorly understood. Here, we show that HSP ‐60/ HSPD 1, a major …
VRK-1 extends life span by activation of AMPK via phosphorylation
Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase.
VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and …
VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and …
MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans
The Golgi apparatus plays a central role in trafficking cargoes such as proteins and lipids.
Defects in the Golgi apparatus lead to various diseases, but its role in organismal longevity is …
Defects in the Golgi apparatus lead to various diseases, but its role in organismal longevity is …