Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac
insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA …

Obesity and diabetes are major public health problems, and are linked to the development
of heart failure. Emerging data highlight the importance of alterations in cardiac energy …

Despite recent advances in therapy, heart failure remains a major cause of mortality and
morbidity and is a growing healthcare burden worldwide. Alterations in myocardial energy …

Alterations in cardiac energy metabolism are an important contributor to the cardiac
pathology associated with obesity, diabetes, and heart failure. High rates of fatty acid β-oxidation …

Background Alterations in cardiac energy metabolism contribute to the development and
severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is …

Rationale: Chronic inflammation in the myocardium is involved in the development of left
ventricular (LV) remodeling and failure after myocardial infarction (MI). Invariant natural killer T (…

Dramatic maturational changes in cardiac energy metabolism occur in the newborn period,
with a shift from glycolysis to fatty acid oxidation. Acetylation and succinylation of lysyl …

Aims Exercise capacity is reduced in heart failure (HF) patients, due mostly to skeletal muscle
abnormalities including impaired energy metabolism, mitochondrial dysfunction, fibre type …

New findings What is the central question of this study? Does angiotensin II directly induce
skeletal muscle abnormalities? What is the main finding and its importance? Angiotensin II …

Background Exercise capacity and quality of life are markedly impaired in chronic kidney
disease (CKD). Increased plasma uremic toxins such as indoxyl sulfate (IS), which induce …