User profiles for Aravinda Chakravarti
 | Aravinda Chakravartiaravinda.chakravarti@nyulangone.org Verified email at nyulangone.org Cited by 185327 |
Population genetics—making sense out of sequence
A Chakravarti - Nature genetics, 1999 - nature.com
The complete human genome nucleotide sequence and technologies for assessing sequence
variation on a genome–scale will prompt comprehensive studies of comparative genomic …
variation on a genome–scale will prompt comprehensive studies of comparative genomic …
Genome-wide association study of blood pressure and hypertension
Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated
with interindividual blood pressure variation have been identified and replicated. Here we …
with interindividual blood pressure variation have been identified and replicated. Here we …
Finding the missing heritability of complex diseases
Genome-wide association studies have identified hundreds of genetic variants associated
with complex human diseases and traits, and have provided valuable insights into their …
with complex human diseases and traits, and have provided valuable insights into their …
Identification of the cystic fibrosis gene: genetic analysis
…, JA Buchanan, D Markiewicz, TK Cox, A Chakravarti… - Science, 1989 - science.org
Approximately 70 percent of the mutations in cystic fibrosis patients correspond to a specific
deletion of three base pairs, which results in the loss of a phenylalanine residue at amino …
deletion of three base pairs, which results in the loss of a phenylalanine residue at amino …
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
Sequence variation in human genes is largely confined to single-nucleotide polymorphisms
(SNPs) and is valuable in tests of association with common diseases and pharmacogenetic …
(SNPs) and is valuable in tests of association with common diseases and pharmacogenetic …
The international HapMap project
…, JG Stewart, DL Valle, LB Jorde, A Chakravarti… - 2003 - deepblue.lib.umich.edu
The goal of the International HapMap Project is to determine the common patterns of DNA
sequence variation in the human genome and to make this information freely available in the …
sequence variation in the human genome and to make this information freely available in the …
Variations on a theme: cataloging human DNA sequence variation
FS Collins, MS Guyer, A Chakravarti - Science, 1997 - science.org
Genetic factors contribute to virtually every human disease, conferring susceptibility or
resistance, or influencing interaction with environmental factors. Much research in both the public …
resistance, or influencing interaction with environmental factors. Much research in both the public …
[HTML][HTML] Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits
The obesity epidemic is responsible for a substantial economic burden in developed countries
and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is …
and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is …
[HTML][HTML] Association between microdeletion and microduplication at 16p11. 2 and autism
Background Autism spectrum disorder is a heritable developmental disorder in which
chromosomal abnormalities are thought to play a role. Methods As a first component of a …
chromosomal abnormalities are thought to play a role. Methods As a first component of a …
DNA duplication associated with Charcot-Marie-Tooth disease type 1A
Charcot-Marie-Tooth disease type 1 A (CMTi A) was localized by genetic mapping to a 3
CM interval on human chromosome 17~. DNA markers within this interval revealed a …
CM interval on human chromosome 17~. DNA markers within this interval revealed a …