Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However, …

10.7554/eLife.39725.001 Several recent papers have reported strong signals of selection
on European polygenic height scores. These analyses used height effect estimates from the …

The selection pressures that have shaped the evolution of complex traits in humans remain
largely unknown, and in some contexts highly contentious, perhaps above all where they …

Given the implications of tumor dynamics for precision medicine, there is a need to
systematically characterize the mode of evolution across diverse solid tumor types. In particular, …

The site frequency spectrum (SFS) has long been used to study demographic history and
natural selection. Here, we extend this summary by examining the SFS conditional on the …

10.7554/eLife.13328.001 Accurate annotation of protein coding regions is essential for
understanding how genetic information is translated into function. We describe riboHMM, a new …

Variation in human complex traits is connected to variation in gene expression, and selection
on complex traits can be reflected in selection on gene expression. Here, Glassberg and …

Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex
interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of …

Gene conversion is the copying of a genetic sequence from a “donor” region to an “acceptor.”
In nonallelic gene conversion (NAGC), the donor and the acceptor are at distinct genetic …

Although gene duplication is an important source of evolutionary innovation, the functional
divergence of duplicates can be opposed by ongoing gene conversion between them. Here, …