lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

…, MB Ardehali, IA Klein, FK Hsieh, AJ Kratkiewicz… - Nature cell …, 2020 - nature.com
Cooperation between DNA, RNA and protein regulates gene expression and controls
differentiation through interactions that connect regions of nucleic acids and protein domains and …

Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy

A Poulet, AJ Kratkiewicz, D Li, JC van Wolfswinkel - Science Advances, 2023 - science.org
Many highly regenerative organisms maintain adult pluripotent stem cells throughout their
life, but how the long-term maintenance of pluripotency is accomplished is unclear. To …

Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in hepatic stellate cells

C Sun, C Zhou, K Daneshvar, AJ Kratkiewicz… - bioRxiv, 2023 - biorxiv.org
Background & Aims: Fibrosis is the common endpoint for all forms of chronic liver injury, and
progression of fibrosis leads to the development of end-stage liver disease. Activation of …

Analysis of creatine kinase expression and regulation throughout C2C12 myogenesis

AJ Kratkiewicz - 2016 - scholarworks.smith.edu
… creatine kinase expression and regulation throughout C2C12" by Arcadia June Kratkiewicz
Kratkiewicz, Arcadia June, "Analysis of creatine kinase expression and regulation throughout …

SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells

PW Reddien, NJ Oviedo, JR Jennings, JC Jenkin… - Science, 2005 - science.org
We have identified two genes, smedwi-1 and smedwi-2, expressed in the dividing adult stem
cells (neoblasts) of the planarian Schmidtea mediterranea. Both genes encode proteins …

Genome-wide location and function of DNA binding proteins

…, EG Jennings, I Simon, J Zeitlinger, J Schreiber… - Science, 2000 - science.org
Understanding how DNA binding proteins control global gene expression and chromosomal
maintenance requires knowledge of the chromosomal locations at which these proteins …

Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration

DE Wagner, IE Wang, PW Reddien - Science, 2011 - science.org
Pluripotent cells in the embryo can generate all cell types, but lineage-restricted cells are
generally thought to replenish adult tissues. Planarians are flatworms and regenerate from tiny …

Comprehensive mapping of long-range interactions reveals folding principles of the human genome

…, M Groudine, A Gnirke, J Stamatoyannopoulos… - science, 2009 - science.org
We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes
by coupling proximity-based ligation with massively parallel sequencing. We constructed …

Acoel genome reveals the regulatory landscape of whole-body regeneration

AR Gehrke, E Neverett, YJ Luo, A Brandt, L Ricci… - Science, 2019 - science.org
INTRODUCTION Although all animals can heal wounds, some are capable of reconstructing
their entire bodies from small fragments of the original organism. Whole-body regeneration …

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics

M Plass, J Solana, FA Wolf, S Ayoub, A Misios… - Science, 2018 - science.org
… We thank J. Alles and A. Boltengagen for help with single-cell sequencing and members of
… We thank J. Alles and A. Boltengagen for help with single-cell sequencing and members of …