Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T FH cells)
is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found …

The Roquin-1 protein binds to messenger RNAs (mRNAs) and regulates gene expression
posttranscriptionally. A single point mutation in Roquin-1, but not gene ablation, increases …

MicroRNAs (miRNAs) are versatile regulators of gene expression with profound implications
for human disease including atherosclerosis, but whether they can exert posttranslational …

Mass spectrometry (MS) is widely used within structural and functional proteomics for a variety
of tasks including protein quality assessment, identification, and characterization. MS is …

Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein implicated in Parkinson
disease (PD); however, the molecular mechanism and mode of action of this protein remain …

Despite the importance of superoxide dismutases (SODs) in the plant antioxidant defence
system little is known about their regulation by post-translational modifications. Here, we …

The stability and homogeneity of a protein sample is strongly influenced by the composition
of the buffer that the protein is in. A quick and easy approach to identify a buffer composition …

Genetic equality between males and females is established by chromosome-wide dosage-compensation
mechanisms. In the fruitfly Drosophila melanogaster, the dosage-…

Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme
A (CoA) biosynthesis: the reversible adenylation of 4′-phosphopantetheine yielding 3′-…

We genetically controlled compartmentalization in eukaryotic cells by heterologous
expression of bacterial encapsulin shell and cargo proteins to engineer enclosed enzymatic …