User profiles for Ariel Alejandro Bazzini
 | Ariel Alejandro BazziniStowers Institute for Medical Research Verified email at stowers.org Cited by 4186 |
Translation affects mRNA stability in a codon-dependent manner in human cells
…, LA Castellano, JM Hand, M Wright, AA Bazzini - elife, 2019 - elifesciences.org
10.7554/eLife.45396.001 mRNA translation decodes nucleotide into amino acid sequences.
However, translation has also been shown to affect mRNA stability depending on codon …
However, translation has also been shown to affect mRNA stability depending on codon …
[HTML][HTML] Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability
Background The regulation of messenger RNA (mRNA) stability has a profound impact on
gene expression dynamics during embryogenesis. For example, in animals, maternally …
gene expression dynamics during embryogenesis. For example, in animals, maternally …
[HTML][HTML] iCodon customizes gene expression based on the codon composition
Messenger RNA (mRNA) stability substantially impacts steady-state gene expression levels
in a cell. mRNA stability is strongly affected by codon composition in a translation-…
in a cell. mRNA stability is strongly affected by codon composition in a translation-…
[HTML][HTML] Coat protein-mediated resistance to TMV infection of Nicotiana tabacum involves multiple modes of interference by coat protein
Expression of tobacco mosaic virus (TMV) coat protein (CP) restricts virus disassembly and
alters the accumulation of the movement protein (MP). To characterize the role of structure of …
alters the accumulation of the movement protein (MP). To characterize the role of structure of …
linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells
Thousands of long intergenic non-coding RNAs (lincRNAs) are transcribed throughout the
vertebrate genome. A subset of lincRNAs enriched in developing brains have recently been …
vertebrate genome. A subset of lincRNAs enriched in developing brains have recently been …
[PDF][PDF] Casting CRISPR-Cas13d to fish for microprotein functions in animal development
AJ Treichel, AA Bazzini - IScience, 2022 - cell.com
Protein coding genes were originally identified with sequence-based definitions that included
a 100-codon cutoff to avoid annotating irrelevant open reading frames. However, many …
a 100-codon cutoff to avoid annotating irrelevant open reading frames. However, many …
iCodon: ideal codon design for customized gene expression
…, G da Silva Pescador, Q Wu, AA Bazzini - bioRxiv, 2021 - biorxiv.org
Messenger RNA (mRNA) stability substantially impacts steady-state gene expression levels
in a cell. mRNA stability, in turn, is strongly affected by codon composition in a translation-…
in a cell. mRNA stability, in turn, is strongly affected by codon composition in a translation-…
[PDF][PDF] CRISPR-Cas13d induces efficient mRNA knockdown in animal embryos
Early embryonic development is driven exclusively by maternal gene products deposited into
the oocyte. Although critical in establishing early developmental programs, maternal gene …
the oocyte. Although critical in establishing early developmental programs, maternal gene …
[HTML][HTML] Optimized CRISPR-RfxCas13d system for RNA targeting in zebrafish embryos
CRISPR-Cas systems have been used to induce DNA mutagenesis for gene function
discovery. However, the development of tools to eliminate RNAs provides complementary and …
discovery. However, the development of tools to eliminate RNAs provides complementary and …
Translation and mRNA stability control
Q Wu, AA Bazzini - Annual review of biochemistry, 2023 - annualreviews.org
… Rachel Scanza, and all Bazzini lab members for suggestions and critical reading of the
manuscript. We also thank Mark Miller for the illustrations. QW thanks the Graduate School of the …
manuscript. We also thank Mark Miller for the illustrations. QW thanks the Graduate School of the …