Matrix metalloproteinase-13 (MMP-13) plays a critical role in the progression of unstable
atherosclerosis. A series of highly potent and selective MMP-13 inhibitors were synthesized …

Purpose Overexpression and activation of matrix metalloproteinase-13 (MMP-13) within
atheroma increases susceptibility to plaque rupture, a major cause of severe cardiovascular …

Overexpression of the NLRP3 inflammasome has been attributed to the progressive worsening
of a multitude of cardiovascular inflammatory diseases such as myocardial infarction, …

Dysfunction of the cardiac sympathetic nervous system contributes to the development of
cardiovascular diseases including ischemia, heart failure, and arrhythmias. Molecular imaging …

Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology. While conventional
wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging …

27 Objectives: Calcific aortic valve disease (CAVD) is the most common valvular disease,
accounting for 50% of all valve disorders and is the third most common cardiovascular disease …

All commercial solvents and chemical reagents were utilized without further purification unless
stated otherwise. All reactions were performed under inert (nitrogen or argon) atmosphere…

2558 Introduction: Matrix metalloproteinases (MMPs) are a class of endopeptidases responsible
for extracellular matrix remodeling. MMP-13 primarily degrades collagen in unstable …

… The automated synthesis of fluorine-18-labelled P1 was developed by Ariel Buchler, a
graduate student in our lab, and uses the GE FX2 N radiochemistry apparatus shown in figure 11 …

Kimberly et al. reported the beneficial effects of IV glyburide on the clinical outcome of brain
edema. We developed the carbon-11 radiolabeled analogue of glyburide to study the body …