INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-differentiated
characteristics. These sex differences have been variously attributed to hormones, …

Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …

The impact of inherited genetic variation on gene expression in humans is well-established.
The majority of known expression quantitative trait loci (eQTLs) impact expression of local …

Expression quantitative trait loci (eQTLs), or single-nucleotide polymorphisms that affect
average gene expression levels, provide important insights into context-specific gene regulation…

Single nucleotide polymorphisms (SNPs) are important drivers of gene expression variation
and downstream phenotypes including disease risk. Single-cell RNA-sequencing (scRNA-…

Understanding the genetics of gene regulation provides information on the cellular mechanisms
through which genetic variation influences complex traits. Expression quantitative trait …

As genome-wide sequencing expands across diverse populations, we are approaching a
comprehensive understanding of the critical roles that genetic variation plays in gene …

Genes work in a coordinated fashion to perform complex functions. Disruption of gene regulatory
programs can result in disease, highlighting the importance of understanding them. We …

In the scenario of real-time monitoring of hospital patients, high-quality inference of patients’
health status using all information available from clinical covariates and lab tests is essential …

… 2015 Ariel Gewirtz …